“H20 + Orthophosphates + Mission City + Corrosion + Origins” – Mac and Desi travel with Bozer to his childhood home when his aunt dies in a tragic accident, however, they soon discover she may have been murdered for trying to expose the city’s contaminated water supply. Also, Riley, Matty and Russ continue to follow leads on their nano-trackers investigation, on MACGYVER, Friday, April 16 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Ernie Hudson and Wendy Raquel Robinson guest star as Bozer’s parents.Pictured: Levy Tran as Desi Nguyen, Lucas Till as Angus "Mac" MacGyver. Pictured: Photo: Fernando Decillis/CBS ©2021 CBS Broadcasting, Inc. All Rights Reserved.

“Barn Find + Oil Slick + La Punzonatura + Lab Rats + Tachometer” – While Mac and the team delve into the world of Italian car culture in order to track down a crime boss-in-hiding, Mac must lean on Desi when he discovers that he losing the ability to control his hands. Also, Mac and Desi move in together and Riley reveals the truth about her secret team of hackers to Russ, on MACGYVER, Friday, April 9 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Tristin Mays as Riley Davis, Lucas Till as Angus "Mac" MacGyver. Photo: Nathan Bolster/CBS ©2021 CBS Broadcasting, Inc. All Rights Reserved.

"C8H7CIO + Nano-Trackers + Resistance + Maldives + Mind Games" -- Mac and Riley head overseas together to prevent a governmental collapse and inadvertently inhale new deadly microscopic technology, on MACGYVER, Friday, March 26 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Tristin Mays as Riley Davis, Lucas Till as Angus "Mac" MacGyver. Photo: Nathan Bolster/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved.

“Diamond + Quake + Carbon + Comms + Tower” – While on a mission to hunt down a Codex lead, Mac and the team discover Murdoc (David Dastmalchian) hacked their comms and has recorded them for months. Now, Mac and the team must stop Murdoc, who is working with Andrews (Joe Pantoliano), as they plot to kill thousands and reveal each Phoenix member’s most-guarded secrets, on MACGYVER, Friday, March 5 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Lucas Till as Angus "Mac" MacGyver. Photo: Mark Hill/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved.

“Rails + Pitons + Pulley + Pipe + Salt” – When Mac and the team are unable to prevent Department of Defense intel from falling into Codex’s hands, Mac must scale a vertical cliff using only gear he can cobble together himself to prevent the info’s transmission, on MACGYVER, Friday, Feb. 19 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Lucas Till as Angus "Mac" MacGyver Photo: CBS ©2021 CBS Broadcasting, Inc. All Rights Reserved.

"SOS + Hazmat + Ultrasound + Frequency + Malihini" -- Mac and team rush to help when Matty's former mentor, Ian Cain (Robert Patrick), and his embassy staff come down with a deadly, mysterious illness. Also, Taylor and Bozer work with Jerry Ortega ("Hawaii Five-0's" Jorge Garcia) to infiltrate a Codex cell, on MACGYVER, Friday, Feb.12 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured:Lucas Till as Angus "Mac" MacGyver, Levy Tran as Desi Nguyen. Photo: Nathan Bolster/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved.

"Golden Lancehead + Venom + Pole Vault + Blood + Baggage" -- The secret experimental cancer treatment Mac's developing with a friend is discovered when culprits ransack their lab, kidnap Mac's partner and plan to use the research to create a powerful new nerve agent, on MACGYVER, Friday, Feb. 5 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Henry Ian Cusick as Russ Taylor, Tristin Mays as Riley Davis, Lucas Till as Angus "Mac" MacGyver, Levy Tran as Desi Nguyen. Photo: Mark Hill/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved.

“Quarantine + N95 + Landline + Telescope + Social Distance” – During COVID-19’s first stay-at-home order, as Mac, Bozer and Riley quarantine together, they try to stop a crime in progress at their neighbor’s house. Also, Russ’ romantic fling takes on a longer and more complicated turn when they quarantine together, on MACGYVER, Friday, Jan. 22 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Levy Tran as Desi Nguyen, Justin Hires as Wilt Bozer, Tristin Mays as Riley Davis, Lucas Till as Angus "Mac" MacGyver. Photo: Nathan Bolster/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved.

"Jack + Kinematics + Safe Cracker + MgKNO3 + GTO" - Using a cryptic postcard as their only clue, Mac and the team must finish the final case, and bring justice, for a fallen friend, on MACGYVER, Friday, Jan. 15 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Lucas Till as Angus "Mac" MacGyver. Photo: Nathan Bolster/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved.

"Banh Bao + Sterno + Drill + Burner + Mason" -- Mac's meeting with Desi's parents goes sideways when her brother finds himself in trouble and desperately needs their help. Also, Russ and Matty must ask an old nemesis for assistance when their new recruitment candidate is kidnapped, on MACGYVER, Friday, Jan. 8 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Page Leong as Mimi, Michael Paul Chan as Danh, Lucas Till as Angus "Mac" MacGyver. Network.Photo: Mark Hill/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved.

“Eclipse + USMC-1856707 + Step Potential + Chain Lock + Ma” – When Russ is kidnapped, Mac and the team must break out a previously murderous psychopath, now pacifist, from prison to help find him. Also, while on the run, Mac and Desi are forced to confront their relationship issues, on MACGYVER, Friday, Dec. 18 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Joe Pantoliano guest stars as Eric Andrews, a murderous psychopath who has found peace and changed his ways. Pictured: Lucas Till as Angus "Mac" MacGyver. Photo: Tom Griscom/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved.

“Resort + Desi + Riley + Window Cleaner + Witness” – Mac and the team infiltrate a glamorous hotel used as an international hideout for criminals in order to find a woman with vital information on Codex. However, their target has a new secret identity that includes a completely new face, on the fifth season premiere of MACGYVER, Friday, Dec. 4 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Levi Tran as Desi Nguyen, Tristin mays as Riley Davis. Photo: Mark Hill/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved.

"Fire + Ashes + Legacy = Phoenix" - Ex-MI6 agent Russ Taylor (Henry Ian Cusick) recruits former Phoenix Foundation members Mac, Riley, Bozer, Matty and Desi to hunt down a bioweapon that's planned to be used by a mysterious organization for a devastating attack on a major U.S. city, on the fourth season premiere of MACGYVER, Friday, Feb. 7 (8:00-9:00 PM, ET/PT) on the CBS Television Network. Pictured: Levy Tran as Desi Nguyen, Tristin Mays as Riley Davis. Photo: Mark Hill/CBS ©2020 CBS Broadcasting, Inc. All Rights Reserved